It seems like even though it was released first, the web series was taken place after the events of the comic book series but then again I don't really remember too much from the comic books cause it's been years since I've read them. The only thing Ican remember is when Ivy is talking to Catwoman and telling her about how they're similar in the sense of they both have good intentions for their crimes. Ivy with her plant saving and Catwoman with her cat saving and Ivy having a flash back during that conversation but Catwoman scoffs her off and Ivy throws some kind of chemical at her. I don't know. Judging from that encounter and how the web series ended where it seemed like Catwoman developed more of a for lack of a better term, trusted bond with Harley and Ivy, I feel like it would make sense if the web series was taken place after the events of the comic books. I wish I could remember more about the comic books. It's been so long. I don't even know if I still have them.