Stephanie Lake was among the team of scientists working for Derek Powers, seeking a cure for his genetic mutation.
Stephanie Lake had just been recently hired to Wayne-Powers when she boldly interpolated Powers with a groundbreaking suggestion ― using his baseline DNA to build a new body, into which they would transfer his neuro-patterns. However, since Dr. Lake had never put that theory into practice, she decided to test it on someone who also had systemically damaged DNA. She then turned to Mr. Freeze, whose human remains were being kept in the laboratory. She convinced Fries to undergo the cloning process, saying that someone with as brilliant a mind as his should be living life again in a rejuvenated body.
The procedure appeared to be successful at first, as Fries awoken in a new, healthy body. Once again living life as Victor Fries, he seemed pleased to go about the world without a need for a containment suit. He also was at peace with the loss of his wife, and proposed a trust fund to make amends for his past misdeeds as Mr. Freeze. Dr. Lake seemed to have a greater interest in Victor Fries than his intellect, and Fries appeared to requit feelings for Stephanie. However, given her later personality it is possible she was toying with Fries' emotions in order to maintain control over him.
Over time, however, Freeze's new body started to revert to its prior state, becoming intolerant to heat. Dr. Lake informed Powers that his body was reverting, and speculated that the cause was a mnemonic agent in his DNA. Powers observed that the only way to be certain was by biopsy Freeze's organs at that stage in order to confirm this and find a way around the problem. Taking this as a suggestion, Dr. Lake locked Mr. Freeze in a room and raised its temperature in an attempt to knock him unconscious. However, Freeze gathered enough strength to break his way out of the lab.
Just as Dr. Lake was reassuring Derek Powers that Mr. Freeze wouldn't come back to settle the score, he laid siege on the building, using a new containment suit. Cornered, Dr. Lake begged Freeze to spare them, but when Powers tried to flee, he froze him anyway, though he broke out using his powers. Then, Dr. Lake claimed they were only trying to help him, to which Freeze replied with the same words she had given him: that there would be some momentary discomfort. He then exacted his revenge on her by freezing her to death, while Lake could do nothing but scream.