Granny Goodness was an inhabitant of Apokolips and the commander of the Female Furies. Though she had the mannerisms of a kindly old lady, she was in fact a cruel tormentor and one of Darkseid's loyalest servants.
Granny ran several orphanages on Apokolips, which she used to recruit the Female Furies.
When the war between Apokolips and New Genesis ended, Darkseid gave his son Orion to Highfather, while Highfather gave his son Scott to Darkseid. However, Darkseid left Scott's raising to Granny Goodness. Granny placed Scott in the X-Pit, where she used every possible method to break his hope and bend him to Darkseid's will.
However, Scott went on to escape the X-Pit, the only person to do so, and, to make matters worse, fell in love with Big Barda, one of Granny's Female Furies, and they escaped Apokolips. Granny considered Scott her greatest failure, and never understood what she did wrong.
Darkseid's war with Superman
When Superman discovered Kara of Argos, Granny was dispatched to create an asteroit magnet todraw a comet into Earth, and recruit Supergirl into the Female Furies. Ultimately, she failed. As punishment, Darkseid has the Furies torture Granny Goodness.
When Darkseid captured Superman, Granny helped in brainwashing him into believing that he was a servant of Darksied. However, once Superman broke free of Darkseid's will, she trapped Granny in the device, incapacitating her and allowing Superman to take on Darkseid, a battle which he won.
After the death of Darkseid in Brainiac's asteroid, Granny emerged as one of the strongest warlords on Apokolips, mainly through the Female Furies. She was opposed by Vermin Vunderbar, who kidnapped Kalibak, Darkseid's son, and imprisoned him in the X-Pit to support his claim to the throne. In respone, Granny kidnapped Oberion, a close friend of Scott and Barda, to blackmail them into rescuing Kalibak so that he could get "proper care". With the aid of the Flash, they succeeded, but Granny decided to kill Oberion anyway. However, before they presented Kalibak to Granny, they swapped him with J'onn J'onzz, who read Granny's mind, allowing them to free Kalibak. Though Barda wanted to kill Granny, it was decided that they would spare her, to continue the power struggle on Apokolips. Thus, Barda didn't leave Granny Goodness dead—she left her with a right hook.
Some months later, the armies of Granny and Vunderbar were poised for a final battle when Darkseid, recently resurrected by Lex Luthor, appeared before both armies. Granny renounced her ambitions and repledged her loyalty to Darkseid.